5 Essential Elements For cees dekker

5 Essential Elements For cees dekker

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‘Yes, that is certainly about ideal. I hunt for a Actual physical understanding of biological devices in a bottom-up way. I do think you can distinguish 3 strains of research in my group at this time. The initial worries chromosome composition: How can you get yourself a metre-extensive DNA polymer folded and organised in such a microscopic cell? We've got formulated visualisation procedures that permit us to review how, by way of example, SMC proteins loop DNA (online video on Youtube) to be able to Construct up chromosomes.

It had been only in the nineties nevertheless, when nanotechnology had Highly developed to your level the place one molecules could possibly be manipulated, that the main experimental gadgets commenced to look.

Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I

Sculpting nano-electrodes by using a transmission electron beam for electrical and geometrical characterization of nanoparticles.

This yielded a breakthrough. Within only some months, we had been ready to measure transportation by way of an individual solitary-walled carbon nanotube. According to small-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering with an Energetic research lab at ceesdekker.net AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with very prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes

What distinguishes biology from chemistry is the fact these elements alongside one another make up a residing system. The key of stated lifetime, I believe, lies in the interactions, the interplay of those molecules. The large question with regard to the origin of existence remains unanswered. How did we ever evolve from uncomplicated molecules in to the particularly complicated devices we see these days? We don't know. I need to work on these kinds of major, open queries.’

Nanopores characterize a chic and functional Resource to evaluate solitary molecules. We analysis novel detection modes with sound-condition nanopores along with different strategies to measure proteins with nanopores. Tasks encompass the following:

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Bulk-surface coupling identifies the mechanistic connection among Min-protein designs in vivo As well as in vitro

Screening pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments

Character Physics many thanks the nameless reviewers for their contribution to your peer assessment of the get the job done.

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Instance (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering in the movement from the DNA rod is shown.